2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride
5-O-Desmethyl Donepezil
CAS: 120013-57-2
Molecular Formula: C23H27NO3
2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride - Names and Identifiers
2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride - Physico-chemical Properties
| Molecular Formula | C23H27NO3 |
| Molar Mass | 365.47 |
| Density | 1.190±0.06 g/cm3(Predicted) |
| Melting Point | 170-172°C |
| Boling Point | 545.3±50.0 °C(Predicted) |
| pKa | 8.16±0.40(Predicted) |
| Storage Condition | -20°C Freezer |
2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride - Introduction
5-O-demethyldonepezil (5-O-Desmethyl Donepezil) is a derivative of Donepezil. It is a white solid powder, stable at room temperature. Its molecular formula is C24H29NO3 and its relative molecular mass is 391.49g/mol.
5-o-demethyldonepezil is primarily used as a cholinesterase inhibitor for the treatment of Alzheimer's disease. It raises acetylcholine levels in the brain, which improves cognitive function and memory.
The preparation of 5-o-demethyldonepezil is generally obtained by performing a chemical reaction on donepezil. Donepezil is first reacted with carbamoyl chloride (or other appropriate acid chloride) to form an amide. The amide then reacts with sodium hydroxide to undergo a demethylation reaction to produce 5-o-demethyldonepezil.
In terms of safety, the toxicity and side effects of 5-o-demethyldonepezil need to be further studied. During use, you should pay attention to the dosage and method of use, and follow the doctor's advice.
5-o-demethyldonepezil is primarily used as a cholinesterase inhibitor for the treatment of Alzheimer's disease. It raises acetylcholine levels in the brain, which improves cognitive function and memory.
The preparation of 5-o-demethyldonepezil is generally obtained by performing a chemical reaction on donepezil. Donepezil is first reacted with carbamoyl chloride (or other appropriate acid chloride) to form an amide. The amide then reacts with sodium hydroxide to undergo a demethylation reaction to produce 5-o-demethyldonepezil.
In terms of safety, the toxicity and side effects of 5-o-demethyldonepezil need to be further studied. During use, you should pay attention to the dosage and method of use, and follow the doctor's advice.
Last Update：2024-04-10 22:29:15
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Multiple SpecificationsSpot supply
Product Name: Donepezil Impurity 28 Visit Supplier Webpage Request for quotationCAS: 120013-57-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: 5-O-Desmethyl Donepezil Visit Supplier Webpage Request for quotation
CAS: 120013-57-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 120013-57-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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